BCG and New Preventive Tuberculosis Vaccines: Implications for Healthcare Workers
نویسندگان
چکیده
منابع مشابه
New vaccines for tuberculosis.
New vaccines are urgently needed if we want to reach the goal of substantially reducing the incidence of tuberculosis by 2050. Despite a steady increase in funding over the past decade, there is still a striking financial shortfall for vaccine research and development for tuberculosis. Yet, around ten vaccine candidates have left the laboratory stage and entered clinical trials. These vaccines ...
متن کاملBCG vaccine and pulmonary tuberculosis
Tuberculosis (TB) is one of the most important public health problems in the world and has been declared as a global emergency by the World Health Organization (WHO) in 1993. Bacillus Calmette-Guérin (BCG) is one of the first developed vaccines to prevent TB. Unfortunately, BCG vaccine has had a limited duration of protection and has shown controversial and variable levels of efficacy, especial...
متن کاملNew tuberculosis vaccines.
The current tuberculosis (TB) vaccine, bacille Calmette-Guerin (BCG), is a live vaccine used worldwide, as it protects against severe forms of the disease, saving thousands of lives every year, but its efficacy against pulmonary forms of TB, responsible for transmission of the diseases, is variable. For more than 80 years now no new TB vaccines have been successfully developed. Over the last de...
متن کاملThe dream of a vaccine against tuberculosis; new vaccines improving or replacing BCG?
In the last 10 yrs, work with experimental laboratory models has developed many new vaccine candidates against tuberculosis (TB). They include subunit vaccines, modified bacilli Calmette-Guérin (BCG) and attenuated Mycobacterium tuberculosis. Phase I clinical trials of new TB vaccine candidates have begun for the first time after 80 yrs of use of BCG. Many of these new trials involve recombinan...
متن کاملRisk of tuberculosis to healthcare workers.
The global uRsurge in tuberculosis (TB), fuelled by the human immunodeficiency virus (HIV) pandemic, and the increase in multidrug-resistant (MDR) TB, has made TB a serious occupational hazard for healthcare workers (HCWs) worldwidel", Recent reports have confirmed a significant risk of occupational infection with Mycobacterium tuberculosis among HCWS,3,4,5 medical students,6 attendants at auto...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2016
ISSN: 1058-4838,1537-6591
DOI: 10.1093/cid/ciw025